Biophysics PhD - IQ Biology
- The Perkins Lab (Molecular, Cellular and Developmental Biology) is collaborating with a theoretical biophysics group to develop a quantitative model to reveal the mechanism of helicase motion. This model provides improved quantitative analysis of DNA stretching data, an essential ingredient for future single-molecule studies.
- In collaboration with Chemical and Biological Engineering department, the Betterton Lab (Physics) is working to formulate and analyze one of the first mathematical models of the dynamics of Smads, the proteins which transmit the TGF-beta signal to the cell nucleus.
- The Betterton Lab (Physics) is also working to develop a new kinetic model for predicting peptide fragmentation mass spectra, using a robust nonlinear optimization algorithm to fit the model parameters.
- The Nesbitt group (Chemical and Biological Engineering and Physics) is interested in the dynamics of how RNA folds into biochemically competent structures, specifically exploiting ultrasensitive laser spectroscopy and microscopy methods to study docking and undocking of RNA tertiary interactions at the single molecule level.
- The Glaser Lab (Physics) and the Betterton Lab (Physics) collaborate in studying biomaterials and cytoskeletal mechanics using molecular simulation and numerical modeling.